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dc.contributor.authorRoos, D.en
dc.contributor.authorWirth, A.en
dc.contributor.authorBurmeister, B.en
dc.contributor.authorSpry, N.en
dc.contributor.authorDrummond, K.en
dc.contributor.authorBeresford, J.en
dc.contributor.authorMcClure, B.en
dc.identifier.citationRadiotherapy and Oncology, 2006; 80(3):318-322en
dc.description.abstractWe evaluated the effect of adjuvant whole brain irradiation (WBI) after surgery or radiosurgery for solitary brain metastases in a Phase III multicentre trial with randomization to 30-36 Gy WBI or observation. The study was closed early due to slow accrual after 19 patients (WBI 10, observation 9). There was no difference in CNS failure-free survival or overall survival between the arms. There was a trend to reduced CNS relapse with WBI (30% versus 78%, P=0.12). Limited analysis of quality of life and neurocognitive function data revealed no evidence of difference between the arms. Our results are not inconsistent with two larger randomized trials and support the use of upfront WBI to decrease brain recurrence in this setting.en
dc.description.statementofresponsibilityRoos, Daniel E. ; Wirth, Andrew ; Burmeister, Bryan H. ; Spry, Nigel A. ; Drummond, Katharine J. ; Beresford, Jennifer A. ; McClure, Beverley E.en
dc.publisherElsevier Sci Ireland Ltden
dc.subjectRadiosurgery; Solitary brain metastases; Surgery; Whole brain irradiationen
dc.titleWhole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05)en
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
Appears in Collections:Medicine publications

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