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https://hdl.handle.net/2440/34700
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Type: | Journal article |
Title: | Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries |
Author: | Kinlay, S. Behrendt, D. Wainstein, M. Beltrame, J. Fang, J. Creager, M. Selwyn, A. Ganz, P. |
Citation: | Circulation, 2001; 104(10):1114-1118 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2001 |
ISSN: | 0009-7322 1524-4539 |
Statement of Responsibility: | Scott Kinlay, Dominik Behrendt, Marco Wainstein, John Beltrame, James C. Fang, Mark A. Creager, Andrew P. Selwyn, and Peter Ganz |
Abstract: | Background - Atherosclerotic coronary arteries are prone to constriction but the underlying causes are incompletely understood. We tested the hypothesis that endothelin-1 (ET-1), a potent vasoconstrictor, contributes to the heightened tone of atherosclerotic human coronary arteries. Methods and Results - In 8 patients with coronary artery disease (CAD) and 8 patients with angiographically smooth coronary arteries (normal), we infused BQ-123, an antagonist of the ETA receptor, into a major coronary artery (infused artery) at 40 nmol/min for 60 minutes. The infused artery in the CAD patients contained a >50% stenosis. Using quantitative angiography, we compared the dilation of the infused artery with another, noninfused coronary artery. To estimate the magnitude of the contribution of ET-1 to coronary tone, we compared the dilation to BQ-123 with that elicited by intracoronary nitroglycerin (200 µg). BQ-123 induced significant dilation in the normal arteries (7.3% at 60 minutes, P<0.001 versus noninfused arteries) and a greater dilation in the CAD arteries (16.3% at 60 minutes, P<0.001 versus infused normal arteries). The dilation at stenoses was particularly pronounced (21.6% at 60 minutes, P<0.001 versus infused CAD arteries). Compared with the dilation from nitroglycerin, ET-1 contributed to 39% of the coronary tone in normal arteries, 74% of tone in CAD arteries, and 106% of tone at stenoses (P<0.01). Conclusions - ET-1 accounts for nearly all the resting tone in atherosclerotic coronary arteries, especially at stenoses. Inhibitors of ET-1, by relieving constriction, may significantly lessen the hemodynamic significance of coronary stenoses and thereby reduce myocardial ischemia. |
Keywords: | Endothelin endothelium vasoconstriction atherosclerosis |
Rights: | © 2001 American Heart Association, Inc. |
DOI: | 10.1161/hc3501.095707 |
Published version: | http://dx.doi.org/10.1161/hc3501.095707 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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