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|Title:||The preparation of side chain functionalized analogues of coenzyme Q for protein conjugation studies|
|Citation:||Organic and Biomolecular Chemistry, 2004; 2(16):2371-2375|
|Publisher:||Royal Soc Chemistry|
|Abstract:||The synthesis of two analogues of CoQ ( 10 and 13) suitable for conjugation to a peptide or protein, and hence the development of an ELISA immunoassay, is presented. These analogues were synthesized from the protected quinone, 1-bromo-2-methyl-3,4,5,6-tetramethoxybenzene ( 1), itself prepared from commercially available CoQ-0 ( 3). Model coupling studies of one of the analogues ( 10) to N-acetyl-L-lysine methyl ester and a lysine containing dipeptide (N-acetyl-glycine-L-lysine methyl ester) were also undertaken as a first step to monoclonial antibody production.|
|Appears in Collections:||Aurora harvest 6|
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