Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/34886
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Type: Journal article
Title: The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K⁺ channels of the alga Nitella hookeri
Other Titles: The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K(+) channels of the alga Nitella hookeri
Author: Giles, K.
Humphries, M.
Abell, A.
Garrill, A.
Citation: Bioorganic and Medicinal Chemistry Letters, 2003; 13(2):293-295
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2003
ISSN: 0960-894X
1464-3405
Statement of
Responsibility: 
Kristian R. Giles, Mark Humphries, Andrew Abell and Ashley Garrill
Abstract: This paper communicates a new synthesis of the ion channel inhibitors NPPB and NPBB using a simple reductive amination sequence. The synthesised compounds were found to reduce channel amplitude of a K⁺ channel present in cytoplasmic droplets of Nitella hookeri.
Keywords: Cytoplasm
Nitrobenzoates
Potassium Channels
Potassium Channel Blockers
Indicators and Reagents
Kinetics
Chlorophyta
Aminobenzoates
Rights: © 2002 Elsevier Science Ltd. All rights reserved.
DOI: 10.1016/S0960-894X(02)00920-4
Appears in Collections:Aurora harvest 6
Chemistry publications

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