Please use this identifier to cite or link to this item:
Type: Journal article
Title: Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus
Author: Clements, R.
Gonzalez, Q.
Long, C.
Wittert, G.
Laws, H.
Citation: American Surgeon, 2004; 70(1):1-4
Publisher: Southeastern Surgical Congress
Issue Date: 2004
ISSN: 0003-1348
Statement of
Clements, Ronald H.; Gonzalez, Quintin H.; Long, Calvin I.; Wittert, Gary; Laws, Henry L.
Abstract: Morbid obesity (MO) is associated with diabetes mellitus-type II (DM-II). Roux-en Y gastric bypass (RNY) has been shown to normalize glucose intolerance in these patients through an incompletely understood mechanism. Gastrointestinal hormonal changes have been suggested as an explanation for resolution of DM II. Preoperatively, 20 MO patients with DM-II were evaluated for demographics and fasting levels of the following: glucose, insulin, C-peptide, glucagon, cortisol, gastric inhibitory polypeptide (GIP), and glucagon-like peptide-1 (GLP-1). Each patient underwent RNY with a 15-cc gastric pouch and 150-cm Roux limb. Postoperatively, each of the variables was measured at 2 weeks, 6 weeks, and 12 weeks and compared with the preoperative result using Student t test with significance, P = 0.05. Results are expressed as mean +/- SD. Twenty patients (5 male and 15 female), age 40.3 +/- 7.9 years, weight 146.3 +/- 34.0 kg, height 158.7 +/- 18.7 cm, and BMI 52.7 +/- 8.8, were enrolled in this IRB-approved protocol. Weight and BMI decreased progressively (117.5 +/- 26.9 kg and 47.0 +/- 7.4, P = 0.01, respectively) during the study but reached significance only at 12 weeks. Fasting plasma glucose decreased significantly within 2 weeks after RNY. Insulin and cortisol both approached, but never achieved, significant changes over 12 weeks. GLP-1 increased initially, but not significantly. GIP and C-peptide both decreased significantly. Glucagon remained essentially unchanged over 12 weeks. RNY rapidly normalizes fasting plasma glucose in morbidly obese patients with DM-II. GIP, a gactor in the enteroinsulin axis, decreases and may play a role in the correction of DM-II after gastric bypass.
Keywords: Humans
Diabetes Mellitus, Type 2
Obesity, Morbid
Gastrointestinal Hormones
Gastric Inhibitory Polypeptide
Blood Glucose
Peptide Fragments
Protein Precursors
Anastomosis, Roux-en-Y
Gastric Bypass
Middle Aged
Glucagon-Like Peptide 1
Description: Copyright © 2004 Southeastern Surgical Congress
Description (link):
Appears in Collections:Aurora harvest 6
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.