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https://hdl.handle.net/2440/40174
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Type: | Journal article |
Title: | Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy |
Author: | Kamil, R. Geier, M. Butler, R. Howarth, G. |
Citation: | Digestive Diseases and Sciences, 2007; 52(5):1247-1252 |
Publisher: | Kluwer Academic/Plenum Publ |
Issue Date: | 2007 |
ISSN: | 0163-2116 1573-2568 |
Statement of Responsibility: | Rasha Kamil, Mark S. Geier, Ross N. Butler and Gordon S. Howarth |
Abstract: | Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (Bb12) were assessed for their potential to prevent indomethacin-induced ulceration in the small intestine of Sprague-Dawley rats. Rats were gavaged skim milk, LGG, or Bb12 twice daily for 14 days. Between days 7–14, rats were gavaged indomethacin (Indo; 6 mg/kg). At sacrifice, small intestine was scored for ulceration and sampled for histologic, immunohistochemical, and myeloperoxidase (MPO) analyses. Indo+LGG-treated rats exhibited a 2.3-fold increase in MPO activity and a 9.8-fold increase in ulceration area compared to Indo-treated controls; these parameters did not differ significantly between Indo+Bb12 and Indo-treated controls. Crypt cell apoptosis decreased by 82% in Indo+Bb12-treated and 55% in Indo+LGG-treated rats compared to Indo-treated controls. Proliferation increased by 209% in Indo+LGG-treated animals compared to Indo-treated controls. Bb12 did not reduce indomethacin-induced intestinal ulceration, whereas LGG actually increased some indicators of injury. LGG and Bb12, at the doses tested, cannot alleviate indomethacin-induced intestinal injury. |
Keywords: | Intestine, Small Animals Rats Rats, Sprague-Dawley Bifidobacterium Intestinal Diseases Peptic Ulcer Disease Models, Animal Indomethacin Peroxidase Apoptosis Cell Proliferation Probiotics Male Lacticaseibacillus rhamnosus |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s10620-006-9443-3 |
Published version: | http://dx.doi.org/10.1007/s10620-006-9443-3 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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