Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/42231
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Type: Journal article
Title: Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans
Author: Feltrin, K.
Little, T.
Meyer, J.
Horowitz, M.
Rades, T.
Wishart, J.
Feinle-Bisset, C.
Citation: Journal of Physiology-London, 2007; 581(2):767-777
Publisher: Blackwell Publishing Ltd
Issue Date: 2007
ISSN: 0022-3751
1469-7793
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Responsibility: 
Kate L. Feltrin, Tanya J. Little, James H. Meyer, Michael Horowitz, Thomas Rades, JudithWishart and Christine Feinle-Bisset
Abstract: Animal studies suggest that the effects of fatty acids on gastric emptying and pancreatic secretion are both concentration and load dependent, while their suppressive effect on energy intake is only load dependent. We postulated that, in humans, the modulation of antropyloroduodenal pressurewaves, plasma cholecystokinin (CCK) and peptideYY(PYY) concentrations and energy intake by intraduodenal lauric acid, a fatty acid with 12 carbon atoms (‘C12’) would be load, but not concentration, dependent. Two groups of 12 healthy males were each studied on three separate occasions in double-blind randomized fashion. Antropyloroduodenal pressure waves, plasma CCK and PYY, and appetite perceptions were measured during intraduodenal infusions of C12 at (1) different loads of (i) 0.2, (ii) 0.3 and (iii) 0.4 kcal min−1 (all 56mM) for 90 min, and (2) different concentrations of (i) 40, (ii) 56 and (iii) 72mM (all 0.4 kcal min−1) for 60 min. Energy intake at a buffet meal consumed immediately following each infusion was quantified. Suppression of antral and duodenal pressure waves, stimulation of pyloric pressure waves, stimulation of plasma CCK and PYY, and suppression of energy intake, were related to the load of C12 administered (r >0.65, P <0.05). In contrast, there were no concentration-dependent effects of C12 on any of these parameters. In conclusion, in humans, the effects of intraduodenal C12 on antropyloroduodenal motility, plasma CCK and PYY and energy intake appear to be related to load, but not concentration, at least at the loads and concentrations evaluated.
Keywords: Duodenum; Upper Gastrointestinal Tract; Pyloric Antrum; Pylorus; Humans; Cholecystokinin; Peptide YY; Lauric Acids; Infusions, Parenteral; Double-Blind Method; Appetite; Energy Intake; Gastrointestinal Motility; Dose-Response Relationship, Drug; Pressure; Time Factors; Reference Values; Adult; Male
RMID: 0020070874
DOI: 10.1113/jphysiol.2007.129650
Published version: http://www.blackwell-synergy.com/doi/pdf/10.1113/jphysiol.2007.129650
Appears in Collections:Medicine publications

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