Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/43011
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Type: Journal article
Title: Carbohydrate intake is the main determinant of growth in infants born <33 weeks' gestation when protein intake is adequate
Author: Collins, C.
Gibson, R.
Miller, J.
McPhee, A.
Willson, K.
Smithers, L.
Makrides, M.
Citation: Nutrition, 2008; 24(5):451-457
Publisher: Elsevier Science Inc
Issue Date: 2008
ISSN: 0899-9007
1873-1244
Statement of
Responsibility: 
Carmel T. Collins, Robert A. Gibson, Jacqueline Miller, Andrew J. McPhee, Kristyn Willson, Lisa G. Smithers, Maria Makrides
Abstract: Objective: We investigated the relative contribution of macronutrients to postnatal growth in preterm infants born <33 wk of gestation. Methods: An audit of daily parenteral and enteral intakes of protein, carbohydrate, fat, energy, and growth (daily weight, weekly length, and head circumference) from birth to discharge home in 138 infants at <33 wk of gestation admitted to an Australian tertiary hospital was done. A mixed-model analysis of variance with random effects (slope and intercept) for subject and controlling for time, sex, gestational age, and total energy was used to determine the relative contribution of macronutrients to growth. Results: A higher energy intake (kilocalories per day) had a positive influence on growth. With total energy held constant, the contribution of carbohydrate to total energy had a positive relation to weight, length, and head circumference gains; protein had no relation and fat was negatively associated. For every 1% increase in energy from carbohydrate, there was a 2.3-g/d increase in weight (95% confidence interval 1.6–3.0, P < 0.0001), a 0.013-cm/d increase in length (95% confidence interval 0.003–0.022, P = 0.007), and a 0.015-cm/d increase in head circumference (95% confidence interval 0.009–0.022, P < 0.0001). Conclusion: A re-examination of the macronutrient balance in the diet of preterm infants is required in relation to optimizing growth.
Keywords: Humans; Birth Weight; Weight Gain; Dietary Carbohydrates; Dietary Proteins; Analysis of Variance; Energy Intake; Nutritional Requirements; Gestational Age; Infant; Infant, Newborn; Infant, Premature; Female; Male; Infant Nutritional Physiological Phenomena
Rights: © 2008 Elsevier Inc. All rights reserved.
RMID: 0020080578
DOI: 10.1016/j.nut.2008.01.014
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/525614/description#description
Appears in Collections:Paediatrics publications

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