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https://hdl.handle.net/2440/43464
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dc.contributor.author | Bell, J. | - |
dc.contributor.author | Chitsaz, M. | - |
dc.contributor.author | Turnidge, J. | - |
dc.contributor.author | Barton, M. | - |
dc.contributor.author | Walters, L. | - |
dc.contributor.author | Jones, R. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Clinical Microbiology, 2007; 45(5):1478-1482 | - |
dc.identifier.issn | 0095-1137 | - |
dc.identifier.issn | 1098-660X | - |
dc.identifier.uri | http://hdl.handle.net/2440/43464 | - |
dc.description.abstract | A negative extended-spectrum beta-lactamase (ESBL) confirmation test result obtained after a positive ESBL screening test result using Clinical and Laboratory Standards Institute methods has been a common occurrence among isolates of Escherichia coli and Klebsiella pneumoniae in the SENTRY Antimicrobial Surveillance Program in the Asia-Pacific region. Among isolates collected between 1998 and 2004 this screen-positive, nonconfirmed profile (failed to show clavulanate synergy) was observed in 8.9% of 4,515 E. coli isolates and 20.3% of 2,303 K. pneumoniae isolates. We then selected 52 E. coli isolates and 68 K. pneumoniae isolates with a negative ESBL confirmation test, as well as comparable number of isolates with confirmed ESBL-positive tests, and examined them for the presence of TEM, SHV, plasmid-borne ampC, and CTX-M genes. We found that 62% of nonconfirming E. coli isolates and 75% of nonconfirming K. pneumoniae harbored a plasmid-borne AmpC enzyme of the CIT or DHA type. The majority of nonconfirming E. coli and K. pneumoniae from the Asia-Pacific region harbor important beta-lactamases, and a positive screening test alone should be sufficient grounds to report resistance to extended-spectrum cephalosporins in this region. | - |
dc.description.statementofresponsibility | Jan M. Bell, Mohsen Chitsaz, John D. Turnidge, Mary Barton, Luke J. Walters, and Ronald N. Jones | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Microbiology | - |
dc.rights | Copyright © 2007, American Society for Microbiology. All Rights Reserved. | - |
dc.source.uri | http://dx.doi.org/10.1128/jcm.02470-06 | - |
dc.subject | Humans | - |
dc.subject | Escherichia coli | - |
dc.subject | Klebsiella pneumoniae | - |
dc.subject | Escherichia coli Infections | - |
dc.subject | Klebsiella Infections | - |
dc.subject | beta-Lactamases | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Population Surveillance | - |
dc.subject | Prevalence | - |
dc.subject | Sensitivity and Specificity | - |
dc.subject | beta-Lactam Resistance | - |
dc.subject | Asia | - |
dc.title | Prevalence and significance of a negative extended-spectrum β-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program | - |
dc.title.alternative | Prevalence and significance of a negative extended-spectrum beta-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/JCM.02470-06 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J. [0000-0003-4240-5578] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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