Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/43633
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Type: Journal article
Title: Antimicrobial compounds from Eremophila serrulata
Author: Ndi, C.
Semple, S.
Griesser, H.
Pyke, S.
Barton, M.
Citation: Phytochemistry, 2007; 68(21):2684-2690
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2007
ISSN: 0031-9422
1873-3700
Statement of
Responsibility: 
Chi P. Ndi, Susan J. Semple, Hans J. Griesser, Simon M. Pyke and Mary D. Barton
Abstract: We report a search for antimicrobial compounds in the Australian plant Eremophila serrulata. Bioassay directed fractionation of a diethyl ether extract prepared from the leaves of E. serrulata led to the isolation of two compounds, an ο-naphthoquinone, 9-methyl-3-(4-methyl-3-pentenyl)-2,3-dihydronaphtho[1,8-bc]pyran-7,8-dione (2), and a serrulatane diterpenoid, 20-acetoxy-8-hydroxyserrulat-14-en-19-oic acid (3). Two other known serrulatane-type diterpenoids, 8,20-dihydroxyserrulat-14-en-19-oic acid (4) and 8,20-diacetoxyserrulat-14-en-19-oic acid (5) were also isolated. None of these compounds had previously been tested for antimicrobial activity. Compounds 2–5 showed antimicrobial activity against Staphylococcus aureus (ATCC 29213) with minimum inhibitory concentrations (MICs) ranging from 15.6 to 250 μg/mL. Compound 2 was the most active with an MIC of 15.6 μg/mL and a minimum bactericidal concentration (MBC) of 125 μg/mL. This compound also showed antimicrobial activity against other Gram-positive bacteria including Streptococcus pyogenes, and Streptococcus pneumoniae. No activity was observed for this compound against all Gram-negative bacteria tested.
Keywords: Staphylococcus aureus; Streptococcus pyogenes; Eremophila Plant; Plant Leaves; Diterpenes; Pyrones; Naphthalenes; Plant Preparations; Anti-Infective Agents; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure
Description: Copyright © 2007 Elsevier Ltd All rights reserved.
RMID: 0020074131
DOI: 10.1016/j.phytochem.2007.05.039
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/273/description#description
Appears in Collections:Chemistry publications

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