Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Antimicrobial compounds from Eremophila serrulata|
|Citation:||Phytochemistry, 2007; 68(21):2684-2690|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Chi P. Ndi, Susan J. Semple, Hans J. Griesser, Simon M. Pyke and Mary D. Barton|
|Abstract:||We report a search for antimicrobial compounds in the Australian plant Eremophila serrulata. Bioassay directed fractionation of a diethyl ether extract prepared from the leaves of E. serrulata led to the isolation of two compounds, an ο-naphthoquinone, 9-methyl-3-(4-methyl-3-pentenyl)-2,3-dihydronaphtho[1,8-bc]pyran-7,8-dione (2), and a serrulatane diterpenoid, 20-acetoxy-8-hydroxyserrulat-14-en-19-oic acid (3). Two other known serrulatane-type diterpenoids, 8,20-dihydroxyserrulat-14-en-19-oic acid (4) and 8,20-diacetoxyserrulat-14-en-19-oic acid (5) were also isolated. None of these compounds had previously been tested for antimicrobial activity. Compounds 2–5 showed antimicrobial activity against Staphylococcus aureus (ATCC 29213) with minimum inhibitory concentrations (MICs) ranging from 15.6 to 250 μg/mL. Compound 2 was the most active with an MIC of 15.6 μg/mL and a minimum bactericidal concentration (MBC) of 125 μg/mL. This compound also showed antimicrobial activity against other Gram-positive bacteria including Streptococcus pyogenes, and Streptococcus pneumoniae. No activity was observed for this compound against all Gram-negative bacteria tested.|
|Keywords:||Staphylococcus aureus; Streptococcus pyogenes; Eremophila Plant; Plant Leaves; Diterpenes; Pyrones; Naphthalenes; Plant Preparations; Anti-Infective Agents; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure|
|Description:||Copyright © 2007 Elsevier Ltd All rights reserved.|
|Appears in Collections:||Chemistry publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.