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Type: Journal article
Title: Traumatic brain injury and Alzheimer's disease: a review
Author: Van Den Heuvel, C.
Thornton, E.
Vink, R.
Citation: Progress in Brain Research, 2007; 161:303-316
Publisher: Elsevier Science Bv
Issue Date: 2007
ISSN: 0079-6123
Statement of
Corinna Van Den Heuvel, Emma Thornton and Robert Vink
Abstract: In an effort to identify the factors that are involved in the pathogenesis of Alzheimer's disease (AD), epidemiological studies have featured prominently in contemporary research. Of those epidemiological factors, accumulating evidence implicates traumatic brain injury (TBI) as a possible predisposing factor in AD development. Exactly how TBI triggers the neurodegenerative cascade of events in AD remains controversial. There has been extensive research directed towards understanding the potential relationship between TBI and AD and the putative influence that apolipoprotein E (APOE) genotype has on this relationship. The aim of the current paper is to provide a critical summary of the experimental and human studies regarding the association between TBI, AD and APOE genotype. It will be shown that despite significant discrepancies in the literature, there still appears to be an increasing trend to support the hypothesis that TBI is a potential risk factor for AD. Furthermore, although it is known that APOE genotype plays an important role in AD, its link to a deleterious outcome following TBI remains inconclusive and ambiguous.
Keywords: Animals; Humans; Brain Injuries; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Apolipoproteins E; Amyloid beta-Peptides
Description: Copyright © 2007 Elsevier B.V. All rights reserved.
RMID: 0020073980
DOI: 10.1016/S0079-6123(06)61021-2
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Appears in Collections:Pathology publications

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