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https://hdl.handle.net/2440/43689
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Type: | Journal article |
Title: | Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis |
Author: | Hill, C. Hunter, D. Niu, J. Clancy, M. Guermazi, A. Genant, H. Gale, D. Grainger, A. Conaghan, P. Felson, D. |
Citation: | Annals of the Rheumatic Diseases, 2007; 66(12):1599-1603 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2007 |
ISSN: | 0003-4967 1468-2060 |
Statement of Responsibility: | Catherine L Hill, David J Hunter, Jingbo Niu, Margaret Clancy, Ali Guermazi, Harry Genant, Daniel Gale, Andrew Grainger, Philip Conaghan, David T Felson |
Abstract: | Objective: To examine the relationship between longitudinal fluctuations in synovitis with change in pain and cartilage in knee osteoarthritis. Methods: Study subjects were patients 45 years of age and older with symptomatic knee osteoarthritis from the Boston Osteoarthritis of the Knee Study. Baseline and follow-up assessments at 15 and 30 months included knee magnetic resonance imaging (MRI), BMI and pain assessment (VAS) over the last week. Synovitis was scored at 3 locations (infrapatellar fat pad, suprapatellar and intercondylar regions) using a semiquantitative scale (0–3) at all 3 time points on MRI. Scores at each site were added to give a summary synovitis score (0–9). Results: We assessed 270 subjects whose mean (SD) age was 66.7 (9.2) years, BMI 31.5 (5.7) kg/m2; 42% were female. There was no correlation of baseline synovitis with baseline pain score (r = 0.09, p = 0.17). The change in summary synovitis score was correlated with the change in pain (r = 0.21, p = 0.0003). An increase of one unit in summary synovitis score resulted in a 3.15-mm increase in VAS pain score (0–100 scale). Effusion change was not associated with pain change. Of the 3 locations for synovitis, changes in the infrapatellar fat pad were most strongly related to pain change. Despite cartilage loss occurring in over 50% of knees, synovitis was not associated with cartilage loss in either tibiofemoral or patellofemoral compartment. Conclusions: Change in synovitis was correlated with change in knee pain, but not loss of cartilage. Treatment of pain in knee osteoarthritis (OA) needs to consider treatment of synovitis. |
Keywords: | Cartilage, Articular Knee Joint Humans Arthralgia Osteoarthritis, Knee Synovitis Disease Progression Magnetic Resonance Imaging Sensitivity and Specificity Follow-Up Studies Aged Middle Aged Female Male |
Description: | Copyright © 2007 BMJ Publishing Group Ltd & European League Against Rheumatism |
DOI: | 10.1136/ard.2006.067470 |
Published version: | http://dx.doi.org/10.1136/ard.2006.067470 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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