Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/43773
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dc.contributor.authorIvell, R.en
dc.date.issued2007en
dc.identifier.citationReproductive Biology and Endocrinology, 2007; 5(15):1-8en
dc.identifier.issn1477-7827en
dc.identifier.issn1477-7827en
dc.identifier.urihttp://hdl.handle.net/2440/43773-
dc.description.abstractThe possession of a scrotum to contain the male gonads is a characteristic feature of almost all mammals, and appears to have evolved to allow the testes and epididymis to be exposed to a temperature a few degrees below that of core body temperature. Analysis of cryptorchid patients, and those with varicocele suggest that mild scrotal warming can be detrimental to sperm production, partly by effects on the stem cell population, and partly by effects on later stages of spermatogenesis and sperm maturation. Recent studies on the effects of clothing and lifestyle emphasize that these can also lead to chronically elevated scrotal temperatures. In particular, the wearing of nappies by infants is a cause for concern in this regard. Together all of the evidence indirectly supports the view that lifestyle factors in addition to other genetic and environmental influences could be contributing to the secular trend in declining male reproductive parameters. The challenge will be to provide relevant and targeted experimental results to support or refute the currently circumstantial evidence.en
dc.description.statementofresponsibilityRichard Ivellen
dc.language.isoenen
dc.publisherBiomed Central Ltd.en
dc.rights© 2007 Ivell; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.source.urihttp://www.rbej.com/content/5/1/15en
dc.subjectScrotum; Animals; Humans; Body Temperature; Life Style; Fertility; Maleen
dc.titleLifestyle impact and the biology of the human scrotumen
dc.typeJournal articleen
dc.identifier.doi10.1186/1477-7827-5-15en
pubs.publication-statusPublisheden
Appears in Collections:Molecular and Biomedical Science publications

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