Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/4394
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DC Field | Value | Language |
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dc.contributor.author | Bowie, J. | - |
dc.contributor.author | Bradford, A. | - |
dc.contributor.author | Tyler, M. | - |
dc.contributor.author | Wallace, J. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Australian Journal of Chemistry: an international journal for chemical science, 1996; 49(12):1325-1331 | - |
dc.identifier.issn | 0004-9425 | - |
dc.identifier.uri | http://hdl.handle.net/2440/4394 | - |
dc.description.abstract | The dorsal glandular extract of the toadlet Uperoleia mjobergii contains more than 20 peptides. We report the amino acid sequences of the seven major peptides: these were determined by a combination of mass spectrometry and automated Edman sequencing. Three of these peptides have 19 amino acid residues and belong to the uperin 2 group of peptides [e.g. uperin 2.6, Gly Ile Leu Asp Ile Ala Lys Lys Leu Val Gly Gly Ile Arg Asn Val Leu Gly Ile (OH)], while the other four have 17 residues and are classified as uperins 3 [e.g. Uperin 3.4, Gly Val Gly Asp Leu Ile Arg Lys Ala Val Ala Ala Ile Lys Asn Ile Val (NH2)]. Several of these cationic peptides have been synthesized in order for bioassays to be carried out: they show significant antibiotic activity against a range of Gram-positive microorganisms. A major skin peptide from the related species Uperoleia inundata is a powerful neuropeptide named uperin 1.1 ([Ala2] uperolein ): no corresponding neuropeptide is detected in the skin glands of Uperoleia mjobergii. | - |
dc.description.statementofresponsibility | AM Bradford, JH Bowie, MJ Tyler and JC Wallace | - |
dc.language.iso | en | - |
dc.publisher | C S I R O PUBLICATIONS | - |
dc.rights | © CSIRO 1996 | - |
dc.source.uri | http://dx.doi.org/10.1071/ch9961325 | - |
dc.title | New antibiotic uperin peptides from the dorsal glands of the Australian toadlet Uperoleia mjobergii | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1071/CH9961325 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Chemistry publications |
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