Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44020
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Type: Journal article
Title: Gonadal steroids and visuo-spatial abilities in adult males: Implications for generalized age-related cognitive decline
Author: Martin, D.
Wittert, G.
Burns, N.
Citation: The Aging Male, 2007; 10(1):17-29
Publisher: Informa Healthcare
Issue Date: 2007
ISSN: 1368-5538
1473-0790
Abstract: The relationship between the gonadal steroids, testosterone and estrogen, and individual and group differences in performance on some cognitive tasks remains unclear but sex differences favoring males on some tests of visuo-spatial ability are large and robust. This aim of this review is to assess evidence for both organizational and activational effects of gonadal steroids as the principle cause of sex difference in visuo-spatial ability. Additionally, the implications of this relationship are discussed in the context of decreasing levels of gonadal steroids in aging males and psychological theories of generalized age-related cognitive decline. Based upon human and non-human research gonadal steroids have organizational effects on visuo-spatial ability in adulthood. Activational effects of gonadal steroids on visuo-spatial ability appear most dominant in older men and are necessary for maintaining optimal visuo-spatial ability; randomized clinical trials show that testosterone supplementation improves performance. Additionally, decreasing gonadal steroid levels in aging males may contribute to generalized age-related cognitive decline. Future supplementation studies in men should attempt to control for constituent abilities related to visuo-spatial task performance, and investigate interactions between dosage levels and baseline gonadal status. Further future animal research is required to investigate changes in gonadal steroid levels and their relationship to neurotransmitter systems, neural plasticity, and behavioral correlates.
Keywords: Humans; Agnosia; Testosterone; Estrogens; Cognition; Aged; Aged, 80 and over; Middle Aged; Male
RMID: 0020073965
DOI: 10.1080/13685530601183537
Appears in Collections:Medicine publications

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