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https://hdl.handle.net/2440/44375
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Type: | Journal article |
Title: | Long-chain polyunsaturated fatty acid (LCPUFA) supplementation for infants born preterm |
Author: | Smithers, L. Gibson, R. Makrides, M. |
Citation: | NeoReviews.org, 2007; 8(4):143-151 |
Publisher: | American Academy of Pediatrics |
Issue Date: | 2007 |
ISSN: | 1526-9906 1526-9906 |
Statement of Responsibility: | Lisa G. Smithers; Robert A. Gibson; Maria Makrides |
Abstract: | During gestation, the placenta actively enriches the fetal circulation with long-chain polyunsaturated fatty acids (LCPUFA), and significant quantities are concentrated in brain and retinal tissues. Preterm infants are denied the usual gestational accretion of LCPUFA, prompting the addition of these fatty acids to preterm formula. Electrophysiologic assessment of visual maturation has shown improved retinal sensitivity and visual acuity with LCPUFA formula supplementation, although the optimal dose has not been determined. Developmental assessment trials of infants fed LCPUFA-supplemented formulas have shown varied results, as have trials assessing the growth of infants fed such formulas. Comparative trials have shown no increased incidence of sepsis, necrotizing enterocolitis, or bronchopulmonary dysplasia among preterm infants fed LCPUFA-supplemented formulas. Further research is required to determine the overall balance of LCPUFA in the diets of preterm infants fed either human milk or infant formula. |
Keywords: | AA: arachidonic acid BPD: bronchopulmonary dysplasia BSID: Bayley Scales of Infant Development CA: corrected age DHA: docosahexaenoic acid EPA: eicosapentaenoic acid ERG: electroretinogram IVH: intraventricular hemorrhage LCPUFA: long-chain polyunsaturated fatty acids MDI: mental development index NEC: necrotizing enterocolitis PDI: psychomotor development index RCT: randomized, controlled trial ROP: retinopathy of prematurity VEP: visual evoked potential |
Description: | Copyright © 2007 by the American Academy of Pediatrics. |
DOI: | 10.1542/neo.8-4-e143 |
Published version: | http://dx.doi.org/10.1542/neo.8-4-e143 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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