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https://hdl.handle.net/2440/44594
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dc.contributor.author | Little, T. | - |
dc.contributor.author | Feltrin, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Meyer, J. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2008; 294(1):WWW 1-WWW 31 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/44594 | - |
dc.description | Copyright © 2008 by the American Physiological Society. | - |
dc.description.abstract | There is evidence from studies in animals that the effects of both fat and CCK on gastrointestinal function and energy intake are attenuated by consumption of a high-fat diet. In humans, the effects of exogenous CCK-8 on antropyloroduodenal motility, plasma CCK, peptide YY (PYY), and ghrelin concentrations, appetite, and energy intake are attenuated by a high-fat diet. Ten healthy lean males consumed isocaloric diets (~15,400 kJ per day), containing either 44% (high-fat, HF) or 9% (low-fat, LF) fat, for 21 days in single-blind, randomized, cross-over fashion. Immediately following each diet (i.e., on day 22), subjects received a 45-min intravenous infusion of CCK-8 (2 ng.kg(-1).min(-1)), and effects on antropyloroduodenal motility, plasma CCK, PYY, ghrelin concentrations, hunger, and fullness were determined. Thirty minutes after commencement of the infusion, subjects were offered a buffet-style meal, from which energy intake (in kilojoules) was quantified. Body weight was unaffected by the diets. Fasting CCK (P < 0.05), but not PYY and ghrelin, concentrations were greater following the HF, compared with the LF, diet. Infusion of CCK-8 stimulated pyloric pressures (P < 0.01) and suppressed antral and duodenal pressures (P < 0.05), with no difference between the diets. Energy intake also did not differ between the diets. Short-term consumption of a HF diet increases fasting plasma CCK concentrations but does not affect upper gut motility, PYY and ghrelin, or energy intake during CCK-8 infusion, in a dose of 2 ng.kg(-1).min(-1), in healthy males. | - |
dc.description.statementofresponsibility | Tanya J. Little, Kate L. Feltrin, Michael Horowitz, James H. Meyer, Judith Wishart, Ian M. Chapman, and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.source.uri | http://ajpregu.physiology.org/cgi/content/abstract/294/1/R45 | - |
dc.subject | antropyloroduodenal motility | - |
dc.subject | appetite | - |
dc.subject | gut hormones | - |
dc.subject | healthy subjects | - |
dc.title | A high-fat diet raises fasting plasma CCK, but does not affect upper gut motility, PYY and ghrelin, or energy intake during CCK-8 infusion in lean men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.00597.2007 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Little, T. [0000-0001-9814-1036] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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