Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/44836
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut |
Author: | Wilson, D. Mattapallil, J. Lay, M. Zhang, L. Roederer, M. Davenport, M. |
Citation: | Journal of Virology, 2007; 81(15):8025-8029 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2007 |
ISSN: | 0022-538X 1098-5514 |
Statement of Responsibility: | David P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport |
Abstract: | CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo. |
Keywords: | Gastrointestinal Tract CD4-Positive T-Lymphocytes Animals Macaca mulatta Humans Simian Acquired Immunodeficiency Syndrome Receptors, CCR5 Viral Load Mathematics Models, Theoretical Simian immunodeficiency virus |
Provenance: | Published ahead of print on 16 May 2007. |
Rights: | © 2007, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/JVI.01771-06 |
Published version: | http://dx.doi.org/10.1128/jvi.01771-06 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.