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Type: Journal article
Title: Periocular squamous cell carcinoma
Author: Limawararut, V.
Leibovitch, I.
Sullivan, T.
Selva-Nayagam, D.
Citation: Clinical and Experimental Ophthalmology, 2007; 35(2):174-185
Publisher: Blackwell Publishing Asia
Issue Date: 2007
ISSN: 1442-6404
Statement of
Vanessa Limawararut, Igal Leibovitch, Tim Sullivan and Dinesh Selva
Abstract: Squamous cell carcinoma (SCC) is the second most common eyelid malignancy and its incidence is increasing. Because of its variable clinical presentation, SCC may be difficult for even the experienced clinician to diagnose. Hence, all suspicious lesions warrant biopsy. As SCC behaviour may range widely in aggression, management should be individualized based on tumour (e.g. size, location, grade, histological subtype, previous recurrence, perineural invasion) and patient factors (e.g. age, health). Treatment of eyelid SCC should include margin control whenever possible for the highest cure rate in this high-risk area. Immediate histological monitoring of surgical margins with frozen sections or Mohs’ micrographic surgery also allows for smaller margins of excision in an area where tissue conservation is important. Other special considerations in the periocular area include maintaining a high level of suspicion for perineural invasion as this may be associated with a poorer prognosis.
Keywords: Humans; Carcinoma, Squamous Cell; Eyelid Neoplasms; Skin Neoplasms; Mohs Surgery; Ophthalmologic Surgical Procedures; Incidence; Survival Rate; Risk Factors
Description: The definitive version is available at
RMID: 0020070334
DOI: 10.1111/j.1442-9071.2006.01411.x
Appears in Collections:Medicine publications

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