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https://hdl.handle.net/2440/44851
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Type: | Journal article |
Title: | Orbital and adnexal sarcoidosis |
Author: | Prabhakaran, V. Saeed, P. Esmaeli, B. Sullivan, T. McNab, A. Davis, G. Valenzuela, A. Leibovitch, I. Kesler, A. Sivak-Callcott, J. Hoyama, E. Selva-Nayagam, D. |
Citation: | JAMA Ophthalmology, 2007; 125(12):1657-1662 |
Publisher: | Amer Medical Assoc |
Issue Date: | 2007 |
ISSN: | 0003-9950 0003-9950 |
Abstract: | <h4>Objective</h4>To present the clinical features and management in a series of patients with orbital and adnexal sarcoidosis.<h4>Methods</h4>This multicenter retrospective study included patients with biopsy-proven noncaseating granuloma involving the orbit or adnexa and evidence of systemic sarcoidosis. Clinical records were reviewed for initial examination findings, radiological findings, treatment modalities, and outcome.<h4>Results</h4>The study included 26 patients (19 female, 7 male; mean age, 52 years). The most common feature at the first examination was a palpable periocular mass followed by discomfort, proptosis, ptosis, dry eye, diplopia, and decreased vision. The disease affected the lacrimal gland (42.3%), orbit (38.5%), eyelid (11.5%), and lacrimal sac (7.7%). Among orbital lesions, the antero-inferior quadrant was preferentially involved. Treatment modalities included steroids, surgical debulking, and methotrexate. During a mean follow-up of 18.75 months, 84.6% of patients showed a complete response to the treatment, but 19.2% of patients developed further signs of sarcoidosis.<h4>Conclusions</h4>Orbital soft tissue involvement is more common in patients older than 50 years and in women. The anterior inferior quadrants of the orbits appear to be preferentially affected. Although a good response to treatment with oral steroids is seen, long-term follow-up is recommended because active systemic disease can develop months to years later. |
Keywords: | Humans Eyelid Diseases Lacrimal Apparatus Diseases Orbital Diseases Sarcoidosis Glucocorticoids Tomography, X-Ray Computed Magnetic Resonance Imaging Debridement Ophthalmologic Surgical Procedures Retrospective Studies Follow-Up Studies Adult Aged Aged, 80 and over Middle Aged Female Male |
Description: | Copyright © 2007 American Medical Association. All Rights Reserved. |
DOI: | 10.1001/archopht.125.12.1657 |
Published version: | http://dx.doi.org/10.1001/archopht.125.12.1657 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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