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https://hdl.handle.net/2440/46368
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Type: | Journal article |
Title: | Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis |
Author: | Leung, H. Colangelo, H. Kee, T. |
Citation: | Langmuir: the ACS journal of surfaces and colloids, 2008; 24(11):5672-5675 |
Publisher: | Amer Chemical Soc |
Issue Date: | 2008 |
ISSN: | 0743-7463 1520-5827 |
Statement of Responsibility: | Mandy H. M. Leung, Hannah Colangelo and Tak W. Kee |
Abstract: | The alkaline hydrolysis of curcumin was studied in three types of micelles composed of the cationic surfactants cetyl trimethylammonium bromide (CTAB) and dodecyl trimethylammonium bromide (DTAB) and the anionic surfactant sodium dodecyl sulfate (SDS). At pH 13, curcumin undergoes rapid degradation by alkaline hydrolysis in the SDS micellar solution. In contrast, alkaline hydrolysis of curcumin is greatly suppressed in the presence of either CTAB or DTAB micelles, with a yield of suppression close to 90%. The results from fluorescence spectroscopic studies reveal that while curcumin remains encapsulated in CTAB and DTAB micelles at pH 13, curcumin is dissociated from the SDS micelles to the aqueous phase at this pH. The absence of encapsulation and stabilization in the SDS micellar solution results in rapid hydrolysis of curcumin. |
Keywords: | Sodium Dodecyl Sulfate Cetrimonium Compounds Curcumin Hydrolysis Micelles Hydrogen-Ion Concentration Quaternary Ammonium Compounds Cetrimonium |
Description: | Copyright © 2008 American Chemical Society |
DOI: | 10.1021/la800780w |
Published version: | http://pubs.acs.org/cgi-bin/abstract.cgi/langd5/2008/24/i11/abs/la800780w.html |
Appears in Collections: | Aurora harvest Chemistry and Physics publications Environment Institute publications |
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