Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/46417
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DC Field | Value | Language |
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dc.contributor.author | Yun, Q. | - |
dc.contributor.author | He, M. | - |
dc.contributor.author | Xing, W. | - |
dc.contributor.author | Bi, J. | - |
dc.contributor.author | Ma, G. | - |
dc.contributor.author | Su, Z. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Biotechnology Letters, 2004; 26(17):1359-1363 | - |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.issn | 1573-6776 | - |
dc.identifier.uri | http://hdl.handle.net/2440/46417 | - |
dc.description | The definitive version may be found at http://www.springerlink.com/ | - |
dc.description.abstract | A novel tetrafunctional reagent, α, γ, α, γ-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSu)4), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoglobin showed a slight decrease in half-saturated O2 pressure value (P50, from 28.1 mm Hg to 21.7 mm Hg) and Hill coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O2 delivery. | - |
dc.description.statementofresponsibility | Qiang Yun, Minglei He, Wenchao Xing, Jingxiu Bi, Guanghui Ma & Zhiguo Su | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic Publ | - |
dc.source.uri | http://www.springerlink.com/content/n82181w362282106/ | - |
dc.subject | blood substitute | - |
dc.subject | bovine hemoglobin | - |
dc.subject | cross-linking reagent | - |
dc.subject | modification | - |
dc.title | A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1023/B:BILE.0000045633.36744.0d | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bi, J. [0000-0001-7056-8572] | - |
Appears in Collections: | Aurora harvest 6 Chemical Engineering publications |
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