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https://hdl.handle.net/2440/46534
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dc.contributor.author | Cukier, K. | - |
dc.contributor.author | Pilichiewicz, A. | - |
dc.contributor.author | Chaikomin, R. | - |
dc.contributor.author | Brennan, I. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2008; 295(2):R459-R462 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.issn | 1522-1490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/46534 | - |
dc.description | Copyright © 2008 by the American Physiological Society. | - |
dc.description.abstract | Background: Postprandial ghrelin suppression arises from the interaction of meal contents with the small intestine and may relate to elevations in blood glucose and/or plasma insulin. Objective: To determine whether the suppression of ghrelin by small intestinal glucose is dependent on the glucose load and can be accounted for by changes in blood glucose and/or plasma insulin. Subjects and methods: Blood glucose, plasma insulin and plasma ghrelin levels were measured in ten healthy males (age: 32 ± 4 yr; body mass index: 25.1 ± 0.4 kg/m2) during intraduodenal glucose infusions at 1 kcal/min ("G1"), 2 kcal/min ("G2") and 4 kcal/min ("G4") and intraduodenal hypertonic saline ("control") for 120 min. Results: There was a progressive decrease in ghrelin with all treatments, control at 45 min and between 90 - 120 min (P < 0.05) and G1 (P < 0.05), G2 (P < 0.0001) and G4 (P < 0.0001) between 30 - 120 min to reach a plateau at ~ 90 min. There was no difference in plasma ghrelin between G1, G2 or G4. Control suppressed ghrelin to a lesser extent than intraduodenal glucose (P < 0.05). The suppression of ghrelin was not related to rises in blood glucose or plasma insulin. Conclusion: Suppression of ghrelin by intraduodenal glucose in healthy males is apparently independent of the glucose load and unrelated to blood glucose or insulin levels. | - |
dc.description.statementofresponsibility | Kimberly Cukier, Amelia N Pilichiewicz, Reawika Chaikomin, Ixchel M Brennan, Judith M. Wishart, Christopher K Rayner, Karen L. Jones, Michael Horowitz, and Christine Feinle-Bisset | - |
dc.language.iso | en | - |
dc.publisher | Amer Physiological Soc | - |
dc.source.uri | http://dx.doi.org/10.1152/ajpregu.00169.2008 | - |
dc.subject | Duodenum | - |
dc.subject | Humans | - |
dc.subject | Insulin | - |
dc.subject | Blood Glucose | - |
dc.subject | Glucose Solution, Hypertonic | - |
dc.subject | Saline Solution, Hypertonic | - |
dc.subject | Double-Blind Method | - |
dc.subject | Random Allocation | - |
dc.subject | Intubation, Gastrointestinal | - |
dc.subject | Kinetics | - |
dc.subject | Reference Values | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.subject | Ghrelin | - |
dc.title | Effect of small intestinal glucose load on plasma ghrelin in healthy men | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1152/ajpregu.00169.2008 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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