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https://hdl.handle.net/2440/46727
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Type: | Journal article |
Title: | Reduced 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma |
Other Titles: | Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma |
Author: | Murphy, V. Zakar, T. Smith, R. Giles, W. Gibson, P. Clifton, V. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2002; 87(4):1660-1668 |
Publisher: | Endocrine Society |
Issue Date: | 2002 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | Vanessa E. Murphy, Tamas Zakar, Roger Smith, Warwick B. Giles, Peter G. Gibson and Vicki L. Clifton |
Abstract: | Pregnancies complicated by asthma are associated with an increased risk of low birth weight. Currently, the mechanisms causing this outcome are unknown. To investigate whether impaired placental function may be a determinant, we measured placental 11ß-hydroxysteroid dehydrogenase type 2 (11ß-HSD2) activity, protein and mRNA, placental CRH mRNA, fetal cortisol, and fetal estriol concentrations at delivery. Asthmatic subjects were classified according to inhaled glucocorticoid intake during pregnancy and compared with a control nonasthmatic group. There was a 25% reduction in neonatal birth weight centile in asthmatic women who did not use inhaled glucocorticoid treatment. This was accompanied by significantly reduced placental 11ß-HSD2 activity, significantly increased fetal cortisol, and a trend toward increased placental CRH mRNA and reduced fetal estriol concentrations. The use of inhaled glucocorticoids for treatment was associated with birth weight centile, 11ß-HSD2 activity, CRH mRNA, fetal cortisol, and estriol concentrations similar to control levels. There was a significant inverse correlation between fetal cortisol and fetal estriol concentrations across all groups. These studies demonstrate that inhaled glucocorticoid intake for the treatment of asthma is associated with improved placental function and fetal outcome, suggesting that inflammatory factors associated with asthma may be detrimental to fetal growth and development in these pregnancies. |
Keywords: | Fetal Blood Placenta Humans Asthma Pregnancy Complications Birth Weight Hydrocortisone Corticotropin-Releasing Hormone Hydroxysteroid Dehydrogenases 11-beta-Hydroxysteroid Dehydrogenase Type 2 RNA, Messenger Glucocorticoids Administration, Inhalation Pregnancy Adult Female |
Description: | Copyright © 2002 by The Endocrine Society |
DOI: | 10.1210/jc.87.4.1660 |
Published version: | http://jcem.endojournals.org/cgi/content/abstract/87/4/1660 |
Appears in Collections: | Aurora harvest 6 Obstetrics and Gynaecology publications |
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