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Type: Journal article
Title: T Cell Proliferation and Apoptosis in HIV-1-Infected Lymphoid Tissue: Impact of Highly Active Antiretroviral Therapy
Author: Dyrhol-Riise, Anne Ma
Ohlsson Teague, Maria
Skarstein, Kathrine
Nygaard, Svein J. T.
Olofsson, Jan
Jonsson, Roland
Asjo, Birgitt
Citation: Clinical Immunology, 2001; 101(2):180-191
Publisher: Academic Press
Issue Date: 2001
ISSN: 1521-6616
School/Discipline: School of Paediatrics and Reproductive Health
Statement of
Anne Ma Dyrhol-Riise, Maria Ohlsson, Kathrine Skarstein, Svein J. T. Nygaard, Jan Olofsson, Roland Jonsson and Birgitt Åsjö
Abstract: T cell turnover was studied in situ in tonsillar lymphoid tissue (LT) from HIV-1-infected individuals during 48 weeks of highly active antiretroviral therapy (HAART) and compared to that of HIV-1-negative controls. Prior to therapy, CD4 cell proliferation (%CD4+ Ki67+) and apoptosis (%CD4+ TUNEL+) were increased in HIV-1-infected LT and both parameters correlated with tonsillar viral load. CD8 cell proliferation (%CD8+ Ki67+) was increased 4- to 10-fold, mainly in the germinal centers. Apoptotic CD8+ T cell levels (%CD8+ TUNEL+) were raised preferentially in the tonsillar T cell zone. The frequency of CD8+ Ki67+ and CD8+ TUNEL+ T cells correlated with tonsillar viral load and with the fraction of CD8+ T cells expressing activation markers. During HAART, CD4 cell turnover normalized while CD8 cell turnover was dramatically reduced. However, low level viral replication concomitant with slightly elevated levels of CD8 cell turnover indicated a persistent cellular immune response in LT. In conclusion, enhanced T cell turnover may reflect effector cells related to HIV-1 infection.
Keywords: HIV-1; tonsils; lymphoid; CD4; CD8; Ki67; TUNEL; turnover; immune activation; therapy; HAART
DOI: 10.1006/clim.2001.5102
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