Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/47032
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Type: Journal article
Title: Intracellular mapping of the distribution of metals derived from the antitumor metallocenes
Author: Waern, J.
Harris, H.
Lai, B.
Cai, Z.
Harding, M.
Dillon, C.
Citation: Journal of Biological Inorganic Chemistry, 2005; 10(5):443-452
Publisher: Springer-Verlag
Issue Date: 2005
ISSN: 0949-8257
1432-1327
Abstract: The intracellular distribution of transition metals in V79 Chinese hamster lung cells treated with subtoxic doses of the organometallic anticancer complexes Cp₂MCl₂, where Cp is η⁵ -cyclopentadienyl and M is Mo, Nb, Ti, or V, has been studied by synchrotron-based X-ray fluorescence (XRF). While significantly higher concentrations of Mo and Nb were found in treated cells compared with control cells, distinct differences in the cellular distribution of each metal were observed. Analysis of thin sections of cells was consistent with some localization of Mo in the nucleus. Studies with a noncytotoxic thiol derivative of molybdocene dichloride showed an uneven distribution of Mo in the cells. For comparison, the low levels of Ti and V in cells treated with the more toxic titanocene and vanadocene complexes, respectively, resulted in metal concentrations at the detection limit of XRF. The results agree with independent chemical studies that have concluded that the biological chemistry of each of the metallocene dihalides is unique.
Keywords: CHO Cells; Animals; Molybdenum; Niobium; Metals; Organometallic Compounds; Antineoplastic Agents; Spectrometry, X-Ray Emission; Molecular Structure; Cricetinae
Description: The original publication can be found at www.springerlink.com
RMID: 0020081439
DOI: 10.1007/s00775-005-0649-1
Published version: http://www.springerlink.com/content/g01202557276n41t/
Appears in Collections:Chemistry and Physics publications
Environment Institute publications

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