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Type: Journal article
Title: Prader Willi Syndrome and excessive daytime sleepiness
Author: Camfferman, D.
McEvoy, R.
O'Donoghue, F.
Lushington, K.
Citation: Sleep Medicine Reviews, 2008; 12(1):65-75
Publisher: W B Saunders Co Ltd
Issue Date: 2008
ISSN: 1087-0792
Abstract: Prader Willi Syndrome (PWS) is a rare genetic disorder characterized by a range of physical, psychological and physiological abnormalities. PWS patients may also demonstrate a range of abnormalities of sleep architecture and of breathing during sleep, and excessive daytime sleepiness (EDS). In the general population EDS is associated with Obstructive Sleep Apnea Syndrome (OSAS). In PWS, by contrast, OSAS is unlikely to fully explain EDS and other factors, including hypothalamic dysfunction are likely to contribute. The present review examines OSAS and hypothalamic dysfunction and other contributing factors to EDS in PWS.
Keywords: Hypothalamus; Humans; Sleep Apnea, Obstructive; Prader-Willi Syndrome; Disorders of Excessive Somnolence; Polysomnography; Body Mass Index; Risk Factors; Age of Onset; Adolescent; Adult; Child
RMID: 0020080239
DOI: 10.1016/j.smrv.2007.08.005
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Appears in Collections:Paediatrics publications

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