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Type: Journal article
Title: Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury
Author: George, G.
Prince, R.
Gailer, J.
Buttigieg, G.
Denton, M.
Harris, H.
Pickering, I.
Citation: Chemical Research in Toxicology, 2004; 17(8):999-1006
Publisher: Amer Chemical Soc
Issue Date: 2004
ISSN: 0893-228X
Statement of
Graham N. George, Roger C. Prince, Jürgen Gailer, Gavin A. Buttigieg, M. Bonner Denton, Hugh H. Harris, and Ingrid J. Pickering
Abstract: Clinical chelation therapy of mercury poisoning generally uses one or both of two drugs--meso-dimercaptosuccinic acid (DMSA) and dimercaptopropanesulfonic acid (DMPS), commercially sold as Chemet and Dimaval, respectively. We have used a combination of mercury L(III)-edge X-ray absorption spectroscopy and density functional theory calculations to investigate the chemistry of interaction of mercuric ions with each of these chelation therapy drugs. We show that neither DMSA nor DMPS forms a true chelate complex with mercuric ions and that these drugs should be considered suboptimal for their clinical task of binding mercuric ions. We discuss the design criteria for a mercuric specific chelator molecule or "custom chelator", which might form the basis for an improved clinical treatment.
Keywords: Mercury Poisoning; Mercury; Succimer; Unithiol; Chelating Agents; Chelation Therapy; Spectrum Analysis
Description: Copyright © 2004 American Chemical Society
RMID: 0020081441
DOI: 10.1021/tx049904e
Appears in Collections:Chemistry and Physics publications
Environment Institute publications

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