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|Title:||Derivatization of 1-phenyl substituted 4-amino-2-benzazepin-3-ones: evaluation of Pd-catalyzed coupling reactions|
De Wachter, Rien
Maes, Bert U. W.
|Citation:||Tetrahedron, 2007; 63(18):3718-3727|
|School/Discipline:||School of Chemistry and Physics : Chemistry|
|Steven Ballet, Rien De Wachter, Bert U.W. Maes, Dirk Tourwé|
|Abstract:||Several Pd-catalyzed reactions were explored to further functionalize the bromo-substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold (Aba). We report in this paper suitable reaction conditions for Suzuki, Buchwald–Hartwig, and Heck reactions. The substitution pattern of the starting aminobenzazepinone turned out to be crucial for the success of these transition metal-catalyzed reactions, which often required modifications of standard literature procedures. The Pd-catalyzed methods provide access to novel substitution patterns of the Aba scaffold.|
|Keywords:||4-Amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones; Pd catalysis; Suzuki reaction; Buchwald–Hartwig reaction; Heck reaction; N-Arylation|
|Appears in Collections:||Chemistry and Physics publications|
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