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Type: Journal article
Title: Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study
Author: Scott, A.
Gunawardana, D.
Wong, J.
Kirkwood, I.
Hicks, R.
Ho Shon, I.
Ramshaw, J.
Robins, P.
Citation: European Journal of Nuclear Medicine and Molecular Imaging, 2009; 36(3):347-353
Publisher: Springer-Verlag
Issue Date: 2009
ISSN: 1619-7070
Statement of
Andrew M. Scott, Dishan H. Gunawardana, Joseph Wong, Ian Kirkwood, Rodney J. Hicks, Ivan Ho Shon, Jayne E. Ramshaw and Peter Robins
Abstract: Purpose: Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. Methods: PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. Results: PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior. Conclusion: PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.
Keywords: Humans
Lymphoma, Non-Hodgkin
Gallium Radioisotopes
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Positron-Emission Tomography
Tomography, X-Ray Computed
Neoplasm Staging
Disease-Free Survival
Prospective Studies
Description: © Springer-Verlag 2008
DOI: 10.1007/s00259-008-0958-z
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