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https://hdl.handle.net/2440/50598
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Type: | Journal article |
Title: | Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study |
Author: | Scott, A. Gunawardana, D. Wong, J. Kirkwood, I. Hicks, R. Ho Shon, I. Ramshaw, J. Robins, P. |
Citation: | European Journal of Nuclear Medicine and Molecular Imaging, 2009; 36(3):347-353 |
Publisher: | Springer-Verlag |
Issue Date: | 2009 |
ISSN: | 1619-7070 1619-7089 |
Statement of Responsibility: | Andrew M. Scott, Dishan H. Gunawardana, Joseph Wong, Ian Kirkwood, Rodney J. Hicks, Ivan Ho Shon, Jayne E. Ramshaw and Peter Robins |
Abstract: | Purpose: Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans. Methods: PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented. Results: PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior. Conclusion: PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma. |
Keywords: | Humans Lymphoma, Non-Hodgkin Gallium Radioisotopes Fluorine Radioisotopes Fluorodeoxyglucose F18 Radiopharmaceuticals Positron-Emission Tomography Tomography, X-Ray Computed Neoplasm Staging Prognosis Disease-Free Survival Prospective Studies |
Description: | © Springer-Verlag 2008 |
DOI: | 10.1007/s00259-008-0958-z |
Published version: | http://dx.doi.org/10.1007/s00259-008-0958-z |
Appears in Collections: | Aurora harvest Medicine publications |
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