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Type: Journal article
Title: One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency
Author: Furness, D.
Fenech, M.
Khong, T.
Romero, R.
Dekker, G.
Citation: American Journal of Obstetrics and Gynecology, 2008; 199(3):276.e1-276.e8
Publisher: Mosby Inc
Issue Date: 2008
ISSN: 0002-9378
Statement of
Denise L.F. Furness, Michael F. Fenech, Yee T. Khong, Roberto Romero and Gustaaf A. Dekker
Abstract: <h4>Objectives</h4>This study was undertaken to test novel genetic polymorphisms involved in 1-carbon metabolism for a potential association with increased risk of developing pregnancy complications associated with uteroplacental insufficiency.<h4>Study design</h4>This was a prospective cohort study consisting of 50 women at low risk and 93 women at high risk for having a pregnancy complication develop. Maternal and fetal DNA samples were genotyped for methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G and methylenetetrahydrofolate dehydrogenase (MTHFD1) G1958A. A chi squared or chi(2) analysis was used to compare genotypes and pregnancy outcome, 1-way analysis of variance and linear regression were used to compare genotype with continuous variables.<h4>Results</h4>The fetal MTR 2756 G allele was associated with uteroplacental insufficiency (P = .022, likelihood ratio = 10.4) and maternal homocysteine (P = .017). The maternal MTR A2756G polymorphism was associated with uteroplacental insufficiency (P = .049, likelihood ratio = 6.0), but only in mothers not supplementing with high-dose B-vitamins. The maternal MTHFD1 AA genotype was associated with intrauterine growth restriction (P = .047, likelihood ratio = 5.8).<h4>Conclusion</h4>This study suggests the maternal and fetal MTR 2756 G allele is an important risk factor in the development of uteroplacental insufficiency. In addition, the maternal MTHFD1 1958 AA genotype may be associated with intrauterine growth restriction.
Keywords: Humans
Fetal Growth Retardation
Placental Insufficiency
Birth Weight
Methylenetetrahydrofolate Dehydrogenase (NADP)
Ferredoxin-NADP Reductase
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Risk Assessment
Risk Factors
Prospective Studies
Maternal Age
Polymorphism, Single Nucleotide
Description: Presented at the 28th Annual Meeting of the Society for Maternal–Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.
DOI: 10.1016/j.ajog.2008.06.020
Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

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