Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/50987
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Noninvasive cardiac flow assessment using high speed magnetic resonance fluid motion tracking
Author: Wong, K.
Kelso, R.
Worthley, S.
Sanders, P.
Mazumdar, J.
Abbott, D.
Citation: PLoS One, 2009; 4(5):e1-e15
Publisher: Public Library of Science
Issue Date: 2009
ISSN: 1932-6203
1932-6203
Editor: Wang, Y.
Statement of
Responsibility: 
Kelvin Kian Loong Wong, Richard Malcolm Kelso, Stephen Grant Worthley, Prashanthan Sanders, Jagannath Mazumdar, Derek Abbott
Abstract: Cardiovascular diseases can be diagnosed by assessing abnormal flow behavior in the heart. We introduce, for the first time, a magnetic resonance imaging-based diagnostic that produces sectional flow maps of cardiac chambers, and presents cardiac analysis based on the flow information. Using steady-state free precession magnetic resonance images of blood, we demonstrate intensity contrast between asynchronous and synchronous proton spins. Turbulent blood flow in cardiac chambers contains asynchronous blood proton spins whose concentration affects the signal intensities that are registered onto the magnetic resonance images. Application of intensity flow tracking based on their non-uniform signal concentrations provides a flow field map of the blood motion. We verify this theory in a patient with an atrial septal defect whose chamber blood flow vortices vary in speed of rotation before and after septal occlusion. Based on the measurement of cardiac flow vorticity in our implementation, we establish a relationship between atrial vorticity and septal defect. The developed system has the potential to be used as a prognostic and investigative tool for assessment of cardiac abnormalities, and can be exploited in parallel to examining myocardial defects using steady-state free precession magnetic resonance images of the heart.
Keywords: Humans
Magnetic Resonance Imaging
Reproducibility of Results
Rheology
Coronary Circulation
Adolescent
Motion
Time Factors
Male
Heart Septal Defects
Rights: Copyright: © 2009 Wong et al.
DOI: 10.1371/journal.pone.0005688
Appears in Collections:Aurora harvest 5
Electrical and Electronic Engineering publications

Files in This Item:
File Description SizeFormat 
hdl_50987.pdfPublished version2.63 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.