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|Title:||Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes|
|Citation:||Bioorganic & Medicinal Chemistry, 2009; 17(17):6329-6339|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Daniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe|
|Abstract:||A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.|
|Keywords:||Bispyridinium; Antifungal activity; Haemolytic activity; Fungal phospholipase B|
|Description:||Available online 23 July 2009.|
|Rights:||Copyright © 2009 Elsevier Ltd. All rights reserved|
|Appears in Collections:||Molecular and Biomedical Science publications|
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