Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51191
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Type: Journal article
Title: Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes
Author: Obando, D.
Pantarat, N.
Handke, R.
Koda, Y.
Widmer, F.
Djordjevic, J.
Ellis, D.
Sorrell, T.
Jolliffe, K.
Citation: Bioorganic & Medicinal Chemistry, 2009; 17(17):6329-6339
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2009
ISSN: 0968-0896
1464-3391
Statement of
Responsibility: 
Daniel Obando, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T. Djordjevic, David H. Ellis, Tania C. Sorrell and Katrina A. Jolliffe
Abstract: A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5′-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4–2.7 μM against reference strains of both Cryptococcus neoformans and Candida albicans.
Keywords: Bispyridinium; Antifungal activity; Haemolytic activity; Fungal phospholipase B
Description: Available online 23 July 2009.
Rights: Copyright © 2009 Elsevier Ltd. All rights reserved
RMID: 0020092226
DOI: 10.1016/j.bmc.2009.07.037
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#description
Appears in Collections:Molecular and Biomedical Science publications

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