Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Hyaluronan synthesis and degradation in cartilage and bone|
|Citation:||Cellular and Molecular Life Sciences, 2008; 65(3):395-413|
|Publisher:||Birkhauser Verlag Ag|
|E. R. Bastow, S. Byers, S. B. Golub, C. E. Clarkin, A. A. Pitsillides and A. J. Fosang|
|Abstract:||Hyaluronan (HA) is a large but simple glycosaminoglycan composed of repeating D-glucuronic acid, β1–3 linked to N-acetyl-D-glucosamine β1–4, found in body fluids and tissues, in both intra- and extracellular compartments. Despite its structural simplicity, HA has diverse functions in skeletal biology. In development, HA-rich matrices facilitate migration and condensation of mesenchymal cells, and HA participates in joint cavity formation and longitudinal bone growth. In adult cartilage, HA binding to aggrecan immobilises aggrecan, retaining it at the high concentrations required for compressive resilience. HA also appears to regulate bone remodelling by controlling osteoclast, osteoblast and osteocyte behaviour. The functions of HA depend on its intrinsic properties, which in turn rely on the degree of polymerisation by HA synthases, depolymerisation by hyaluronidases, and interactions with HA-binding proteins. HA synthesis and degradation are closely regulated in skeletal tissues and aberrant synthetic or degradative activity causes disease. The role and regulation of HA synthesis and degradation in cartilage, bone and skeletal development is discussed.|
|Keywords:||Hyaluronan; hyaluronan synthase; hyaluronidase; cartilage; bone; growth plate; skeletal development; limb morphogenesis|
|Appears in Collections:||Molecular and Biomedical Science publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.