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https://hdl.handle.net/2440/51940
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dc.contributor.author | Patel, V. | - |
dc.contributor.author | Cooper, S. | - |
dc.contributor.author | Deakin, J. | - |
dc.contributor.author | Fulton, B. | - |
dc.contributor.author | Graves, T. | - |
dc.contributor.author | Warren, W. | - |
dc.contributor.author | Wilson, R. | - |
dc.contributor.author | Graves, J. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | BMC Biology, 2008; 6(1):34-55 | - |
dc.identifier.issn | 1741-7007 | - |
dc.identifier.issn | 1741-7007 | - |
dc.identifier.uri | http://hdl.handle.net/2440/51940 | - |
dc.description.abstract | Background: Vertebrate alpha (α)- and beta (β)-globin gene families exemplify the way in which genomes evolve to produce functional complexity. From tandem duplication of a single globin locus, the α- and β-globin clusters expanded, and then were separated onto different chromosomes. The previous finding of a fossil β-globin gene (ω) in the marsupial α-cluster, however, suggested that duplication of the α-β cluster onto two chromosomes, followed by lineage-specific gene loss and duplication, produced paralogous α- and β-globin clusters in birds and mammals. Here we analyse genomic data from an egg-laying monotreme mammal, the platypus (Ornithorhynchus anatinus), to explore haemoglobin evolution at the stem of the mammalian radiation. Results: The platypus α-globin cluster (chromosome 21) contains embryonic and adult α- globin genes, a β-like ω-globin gene, and the GBY globin gene with homology to cytoglobin, arranged as 5'-ζ-ζ'-αD-α3-α2-α1-ω-GBY-3'. The platypus β-globin cluster (chromosome 2) contains single embryonic and adult globin genes arranged as 5'-ε-β-3'. Surprisingly, all of these globin genes were expressed in some adult tissues. Comparison of flanking sequences revealed that all jawed vertebrate α-globin clusters are flanked by MPG-C16orf35 and LUC7L, whereas all bird and mammal β-globin clusters are embedded in olfactory genes. Thus, the mammalian α- and β-globin clusters are orthologous to the bird α- and β-globin clusters respectively. Conclusion: We propose that α- and β-globin clusters evolved from an ancient MPG-C16orf35-α-β-GBY-LUC7L arrangement 410 million years ago. A copy of the original β (represented by ω in marsupials and monotremes) was inserted into an array of olfactory genes before the amniote radiation (>315 million years ago), then duplicated and diverged to form orthologous clusters of β-globin genes with different expression profiles in different lineages. | - |
dc.description.statementofresponsibility | Vidushi S. Patel, Steven J.B. Cooper, Janine E. Deakin, Bob Fulton, Tina Graves, Wesley C. Warren, Richard K. Wilson and Jennifer A.M. Graves | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1186/1741-7007-6-34 | - |
dc.subject | Chromosomes, Artificial, Bacterial | - |
dc.subject | Animals | - |
dc.subject | Birds | - |
dc.subject | Mammals | - |
dc.subject | Platypus | - |
dc.subject | Globins | - |
dc.subject | DNA Transposable Elements | - |
dc.subject | Blotting, Southern | - |
dc.subject | In Situ Hybridization, Fluorescence | - |
dc.subject | Cloning, Molecular | - |
dc.subject | Polymerase Chain Reaction | - |
dc.subject | Sequence Analysis, DNA | - |
dc.subject | Evolution, Molecular | - |
dc.subject | Phylogeny | - |
dc.subject | Multigene Family | - |
dc.subject | Models, Genetic | - |
dc.subject | Promoter Regions, Genetic | - |
dc.title | Platypus globin genes and flanking loci suggest a new insertional model for beta-globin evolution in birds and mammals | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/1741-7007-6-34 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cooper, S. [0000-0002-7843-8438] | - |
Appears in Collections: | Aurora harvest Earth and Environmental Sciences publications Environment Institute Leaders publications |
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