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https://hdl.handle.net/2440/52160
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dc.contributor.author | Parida, L. | - |
dc.contributor.author | Mele, M. | - |
dc.contributor.author | Calafell, F. | - |
dc.contributor.author | Bertranpetit, J. | - |
dc.contributor.author | Schurr, T. | - |
dc.contributor.author | Santos, F. | - |
dc.contributor.author | Quintana-Murci, L. | - |
dc.contributor.author | Comas, D. | - |
dc.contributor.author | Tyler-Smith, C. | - |
dc.contributor.author | Zalloua, P. | - |
dc.contributor.author | Balanovska, E. | - |
dc.contributor.author | Balanovsky, O. | - |
dc.contributor.author | Behar, D. | - |
dc.contributor.author | Mitchell, R. | - |
dc.contributor.author | Jin, L. | - |
dc.contributor.author | Soodyall, H. | - |
dc.contributor.author | Pitchappan, R. | - |
dc.contributor.author | Cooper, A. | - |
dc.contributor.author | Royyuru, A. | - |
dc.contributor.author | Rosset, S. | - |
dc.contributor.author | et al. | - |
dc.contributor.other | Cooper, Alan | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Computational Biology, 2008; 15(9):1133-1153 | - |
dc.identifier.issn | 1066-5277 | - |
dc.identifier.issn | 1557-8666 | - |
dc.identifier.uri | http://hdl.handle.net/2440/52160 | - |
dc.description | Copyright © Mary Ann Liebert, Inc. University of Adelaide consortium member: Alan Cooper | - |
dc.description.abstract | Traditionally nonrecombinant genome, i.e., mtDNA or Y chromosome, has been used for phylogeography, notably for ease of analysis. The topology of the phylogeny structure in this case is an acyclic graph, which is often a tree, is easy to comprehend and is somewhat easy to infer. However, recombination is an undeniable genetic fact for most part of the genome. Driven by the need for a more complete analysis, we address the problem of estimating the ancestral recombination graph (ARG) from a collection of extant sequences. We exploit the coherence that is observed in the human haplotypes as patterns and present a network model of patterns to reconstruct the ARG. We test our model on simulations that closely mimic the observed haplotypes and observe promising results. | - |
dc.description.statementofresponsibility | Laxmi Parida, Marta Mele, Francesc Calafell, Jaume Bertranpetit and The Genographic Consortium | - |
dc.language.iso | en | - |
dc.publisher | Mary Ann Liebert Inc Publ | - |
dc.source.uri | http://dx.doi.org/10.1089/cmb.2008.0065 | - |
dc.subject | Genographic Consortium | - |
dc.subject | Chromosomes, Human, Y | - |
dc.subject | Humans | - |
dc.subject | DNA, Mitochondrial | - |
dc.subject | Phylogeny | - |
dc.subject | Recombination, Genetic | - |
dc.subject | Haplotypes | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Multigene Family | - |
dc.subject | Algorithms | - |
dc.subject | Models, Genetic | - |
dc.title | Estimating the ancestral recombinations graph (ARG) as compatible networks of SNP patterns | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1089/cmb.2008.0065 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cooper, A. [0000-0002-7738-7851] | - |
Appears in Collections: | Aurora harvest Australian Centre for Ancient DNA publications Earth and Environmental Sciences publications Environment Institute Leaders publications |
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