Bone remodeling: A review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip
Date
2008
Authors
Fazzalari, N.
Editors
Advisors
Journal Title
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Volume Title
Type:
Journal article
Citation
Seminars in Cell and Developmental Biology, 2008; 19(5):467-472
Statement of Responsibility
Nicola L. Fazzalari
Conference Name
Abstract
Bone remodeling is an active process throughout the skeleton. The concept of bone turnover surface has been developed and reported in the peer reviewed literature as the quotient of formation surface/resorption surface and is significantly lower in hip fracture. It is necessary to identify the molecular drivers of these changes in bone turnover. Factors that have been strongly implicated in bone metabolism are therefore divided into three categories, "Vascular", "Anabolic" and "Catabolic". Further data is required from the bone tissue-level microenvironment, of fragility fracture patients, on the variation in molecular signals, and the associated changes in bone structure and remodeling.
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Dissertation Note
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Crown copyright © 2008 Published by Elsevier Ltd.