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Type: Journal article
Title: Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats
Author: Beig, M.
Baumert, M.
Walker, F.
Day, T.
Nalivaiko, E.
Citation: Neuroscience, 2009; 159(3):1185-1191
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2009
ISSN: 0306-4522
Statement of
M.I. Beig, M. Baumert, F.R. Walker, T.A. Day and E. Nalivaiko
Abstract: The aim of this study was to determine whether 5-HT2A receptors mediate cardiovascular and thermogenic responses to acute psychological stresses. For this purpose, adult male Wistar hooded rats instrumented for telemetric recordings of either electrocardiogram (ECG) (n=12) or arterial pressure (n=12) were subjected, on different days, to four 15-min episodes of social defeat. Prior to stress, animals received s.c. injection of the selective 5-HT2A receptor antagonist SR-46349B (trans-4-((3Z)3-[(2-dimethylaminoethyl)oxyimino]-3-(2-fluorophenyl)propen-1-yl)-phenol, hemifumarate) (at doses of 0.3, 1.0 and 3.0 mg/kg) or vehicle. The drug had no effect on basal heart rate or heart rate variability indexes, arterial pressure, and core body temperature. Social defeat elicited significant and substantial tachycardic (347+/-7 to 500+/-7 bpm), pressor (77+/-4 to 97+/-4 mm Hg) and hyperthermic (37.0+/-0.3 to 38.5+/-0.1 degrees C) responses. Blockade of 5-HT2A receptors, at all doses of the antagonist, completely prevented stress-induced hyperthermia. In contrast, stress-induced cardiovascular responses were not affected by the blockade (except small reduction of tachycardia by the highest dose of the drug). We conclude that in rats, 5-HT2A receptors mediate stress-induced hyperthermic responses, but are not involved in the genesis of stress-induced rises in heart rate or arterial pressure, and do not participate in cardiovascular control at rest.
Keywords: Cardiovascular System
Rats, Wistar
Receptor, Serotonin, 5-HT2A
Serotonin Antagonists
Body Temperature
Analysis of Variance
Stress, Psychological
Social Dominance
Blood Pressure
Heart Rate
Serotonin 5-HT2 Receptor Antagonists
Description: Copyright © 2009 IBRO Published by Elsevier Ltd.
DOI: 10.1016/j.neuroscience.2009.01.038
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Appears in Collections:Aurora harvest
Electrical and Electronic Engineering publications

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