Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/52674
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Transient, early release of glucagon-like peptide-1 during low rates of intraduodenal glucose delivery
Author: Kuo, P.
Chaikomin, R.
Pilichiewicz, A.
O'Donovan, D.
Wishart, J.
Meyer, J.
Jones, K.
Feinle-Bisset, C.
Horowitz, M.
Rayner, C.
Citation: Regulatory Peptides, 2008; 146(1-3):1-3
Publisher: Elsevier Science BV
Issue Date: 2008
ISSN: 0167-0115
1873-1686
Statement of
Responsibility: 
Paul Kuo, Reawika Chaikomin, Amelia Pilichiewicz, Deirdre O’Donovan, Judith M. Wishart, James H. Meyer, Karen L. Jones, Christine Feinle-Bisset, Michael Horowitz and Christopher K. Rayner
Abstract: CONTEXT: The "incretin" hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), account for some 60% of the stimulation of insulin by oral glucose, but the determinants of their secretion from the small intestine are poorly understood. Cells which release GIP (K cells) are localized to the proximal small intestine, while GLP-1 releasing cells (L cells) predominate in the distal gut. It has been suggested that a threshold rate of duodenal glucose delivery (approximately 1.8 kcal/min) needs to be exceeded for stimulation of GLP-1. OBJECTIVE: To determine whether a low intraduodenal glucose load (1 kcal/min) has the capacity to stimulate GLP-1, and if so, the characteristics of the response. DESIGN: Retrospective analysis of all studies in our laboratory involving healthy humans administered intraduodenal glucose at 1 kcal/min for 120 min. SETTING: Clinical research laboratory. PARTICIPANTS: 27 healthy subjects (24 male; age 36+/-3 years; BMI 25.2+/-0.7 kg/m(2)). MAIN OUTCOME MEASURES: Plasma GLP-1, GIP, insulin, and blood glucose concentrations, reported as mean+/-SEM. RESULTS: During intraduodenal glucose, plasma GLP-1 increased at 15 and 30 min (P<0.001 for both) and returned to baseline thereafter. In contrast, there were sustained increases in plasma GIP (P<0.001), insulin (P<0.001), and blood glucose (P<0.001). CONCLUSION: In healthy subjects, there is early, transient stimulation of GLP-1 by glucose loads hitherto believed to be "sub-threshold". The mechanisms underlying this effect, which could be attributed to initially rapid transit to jejunal L cells, or a duodeno-jejunoileal neural or hormonal loop, remain to be determined.
Keywords: Intestine, Small; Duodenum; Humans; Gastric Inhibitory Polypeptide; Insulin; Glucose; Blood Glucose; Retrospective Studies; Intubation, Gastrointestinal; Adult; Female; Male; Glucagon-Like Peptide 1
Description: Copyright © 2007 Elsevier B.V. All rights reserved.
RMID: 0020080272
DOI: 10.1016/j.regpep.2007.09.032
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/506031/description#description
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.