Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Evidence that obesity alters the quality of oocytes and embryos|
|Citation:||Pathophysiology, 2008; 15(2):115-121|
|Rebecca L. Robker|
|Abstract:||Infertility is more common in overweight and obese women, with reproductive impairments occurring at many levels of the hypothalamic-ovarian-uterine axis. These impairments lead primarily to longer times to conception and decreased pregnancy rates and have resulted in increasing numbers of overweight and obese women seeking assisted reproduction technologies, such as in vitro fertilization or IVF. Even after undertaking IVF procedures obese women have decreased pregnancy rates compared to moderate weight women, suggesting there may be intrinsic differences in the oocytes of these patients. Definitive data is lacking however, and thus the effect of obesity on oocyte quality remains one of the biggest controversies in reproductive medicine. This review summarizes the studies to date which have yielded information about the effects of obesity on human oocyte quality and pre-implantation embryo development. In addition recent results from our laboratory which clearly demonstrate that diet-induced obesity in mice impairs oocyte developmental competence are discussed.|
|Keywords:||Obesity; Female fertility; Oocyte; Embryo; Body mass index (BMI); In vitro fertilization (IVF); Assisted reproduction technologies (ART)|
|Appears in Collections:||Obstetrics and Gynaecology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.