Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/53452
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Type: Journal article
Title: Gastrointestinal symptoms and glycemic control in diabetes mellitus: a longitudinal population study
Author: Quan, C.
Talley, N.
Jones, M.
Howell, S.
Horowitz, M.
Citation: European Journal of Gastroenterology & Hepatology, 2008; 20(9):888-897
Publisher: Lippincott Williams & Wilkins
Issue Date: 2008
ISSN: 0954-691X
1473-5687
Statement of
Responsibility: 
Quan Carolyn, Talley Nicholas J., Jones Michael, Howell Stuart and Horowitz, Michael
Abstract: Background: The prevalence of gastrointestinal (GI) symptoms is increased in diabetes, but their natural history is understood poorly and any impact of glycemic control is controversial. We aimed to quantify changes in GI symptom status and glycemic control among a population sample of patients with diabetes. Methods: Data on 10 chronic GI symptom complexes were obtained from a validated questionnaire at baseline and after 12 months. Changes in acute and chronic glycemic control were classified as always adequate, variable (deteriorated or improved), or always inadequate; acute glycemic control was assessed by fasting plasma glucose and chronic glycemic control by a validated self-report 5-point graded scale. Results: Baseline and follow-up data were available in 136 individuals with diabetes (mean age 59 years; 66% males; 95% type 2). The most prevalent GI symptom complexes were abdominal bloating/distension (35%), ulcer-like dyspepsia (35%), and irritable bowel syndrome (27%). Overall, between 7 and 24% reported a change in GI symptoms with the largest change in irritable bowel syndrome (24%), bloating/distension (22%), and ulcer-like dyspepsia (21%). Those who had a change in abdominal bloating (either loss or gain) over 12 months were more likely to have increased their mean fasting plasma glucose (P<0.05). Contrary to expectations, consistently poor self-reported glycemic control was only weakly associated with less persistent abdominal pain (r=-0.2, P=0.03), diarrhea (r=-0.22, P=0.01), and abdominal bloating (r=-0.2, P=0.03). Acute glycemic control was not significantly related to any GI symptoms. Conclusion: We were unable to demonstrate any association between worsening GI symptoms and glycemic control
Keywords: Humans; Gastrointestinal Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hyperglycemia; Diabetes Complications; Blood Glucose; Epidemiologic Methods; Quality of Life; Adult; Aged; Middle Aged; New South Wales; Female; Male
Rights: © 2008 Lippincott Williams & Wilkins, Inc.
RMID: 0020082734
DOI: 10.1097/MEG.0b013e3282f5f734
Appears in Collections:Medicine publications

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