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https://hdl.handle.net/2440/54034
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dc.contributor.author | Petursdottir, A. | - |
dc.contributor.author | Farr, S. | - |
dc.contributor.author | Morley, J. | - |
dc.contributor.author | Banks, W. | - |
dc.contributor.author | Skuladottir, G. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 2008; 63(11):1153-1160 | - |
dc.identifier.issn | 1079-5006 | - |
dc.identifier.issn | 1758-535X | - |
dc.identifier.uri | http://hdl.handle.net/2440/54034 | - |
dc.description.abstract | Animal studies have shown that a deficiency in brain of the n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with memory loss and diminished cognitive function. The senescence-accelerated prone 8 (SAMP8) mouse develops impairments in learning and memory at 8–12 months of age. The effect of diet supplemented with n-3 PUFA on brain phospholipid DHA status, learning, and memory ability in aged SAMP8 mice was investigated. At the age of 10 months, SAMP8 mice were fed either a low-DHA or a high-DHA diet for 8 weeks. In comparison to SAMP8 mice fed the low-DHA diet, those fed a high-DHA diet had improved acquisition and retention in a T-maze foot shock avoidance test and a higher proportion of DHA in hippocampal and amygdala phospholipids. This study demonstrates that, in mature animals, DHA is incorporated into brain phospholipids and that dietary n-3 PUFA is associated with delay in cognitive decline. | - |
dc.description.statementofresponsibility | Anna L. Petursdottir, Susan A. Farr, John E. Morley, William A. Banks and Gudrun V. Skuladottir | - |
dc.language.iso | en | - |
dc.publisher | Gerontological Society of America | - |
dc.rights | Copyright 2008 by The Gerontological Society of America | - |
dc.source.uri | http://biomed.gerontologyjournals.org/cgi/content/abstract/63/11/1153 | - |
dc.subject | Alzheimer's disease | - |
dc.subject | n-3 Polyunsaturated fatty acids | - |
dc.subject | Docosahexaenoic acid | - |
dc.subject | Hippocampus | - |
dc.subject | Memory | - |
dc.title | Effect of dietary n-3 polyunsaturated fatty acids on brain lipid fatty acid composition, learning ability, and memory of senescence-accelerated mouse | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/gerona/63.11.1153 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Morley, J. [0000-0001-6444-2965] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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