Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: A randomized controlled trial
Author: Makrides, M.
Gibson, R.
McPhee, A.
Collins, C.
Davis, P.
Doyle, L.
Simmer, K.
Colditz, P.
Morris, S.
Smithers, L.
Willson, K.
Ryan, P.
Citation: JAMA: Journal of the American Medical Association, 2009; 301(2):175-182
Publisher: Amer Medical Assoc
Issue Date: 2009
ISSN: 0098-7484
Statement of
Maria Makrides, Robert A. Gibson, Andrew J. McPhee, Carmel T. Collins, Peter G. Davis, Lex W. Doyle, Karen Simmer, Paul B. Colditz, Scott Morris, Lisa G. Smithers, Kristyn Willson, Philip Ryan
Abstract: <h4>Context</h4>Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on the neurodevelopment of preterm infants.<h4>Objective</h4>To determine the effect of meeting the estimated DHA requirement of preterm infants on neurodevelopment at 18 months' corrected age.<h4>Design, setting, and participants</h4>Randomized, double-blind controlled trial enrolling infants born at less than 33 weeks' gestation from April 2001 to October 2005 at 5 Australian tertiary hospitals, with follow-up to 18 months.<h4>Intervention</h4>High-DHA (approximately 1% total fatty acids) enteral feeds compared with standard DHA (approximately 0.3% total fatty acids) from day 2 to 4 of life until term corrected age.<h4>Main outcome measures</h4>Bayley Mental Development Index (MDI) at 18 months' corrected age. A priori subgroup analyses were conducted based on randomization strata (sex and birth weight < 1250 g vs > or = 1250 g).<h4>Results</h4>Of the 657 infants enrolled, 93.5% completed the 18-month follow-up. Bayley MDI scores did not differ between the high- and standard-DHA groups (mean difference, 1.9; 95% confidence interval [CI], -1.0 to 4.7). The MDI among girls fed the high-DHA diet was higher than girls fed standard DHA in unadjusted and adjusted analyses (unadjusted mean difference, 4.7; 95% CI, 0.5-8.8; adjusted mean difference, 4.5; 95% CI, 0.5-8.5). The MDI among boys did not differ between groups. For infants born weighing less than 1250 g, the MDI in the high-DHA group was higher than with standard DHA in the unadjusted comparison (mean difference, 4.7; 95% CI, 0.2-9.2) but did not reach statistical significance following adjustment for gestational age, sex, maternal education, and birth order (mean difference, 3.8; 95% CI, -0.5 to 8.0). The MDI among infants born weighing at least 1250 g did not differ between groups.<h4>Conclusion</h4>A DHA dose of approximately 1% total fatty acids in early life did not increase MDI scores of preterm infants overall born earlier than 33 weeks but did improve the MDI scores of girls.<h4>Trial registration</h4> Identifier: ACTRN12606000327583.
Keywords: Humans
Docosahexaenoic Acids
Double-Blind Method
Child Development
Neuropsychological Tests
Dietary Supplements
Infant, Newborn
Infant, Premature
DOI: 10.1001/jama.2008.945
Appears in Collections:Aurora harvest
Paediatrics publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.