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https://hdl.handle.net/2440/56690
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Type: | Journal article |
Title: | Pregnancy and maternal outcomes among kidney transplant recipients |
Author: | Levidiotis, V. Chang, S. McDonald, S. |
Citation: | Journal of the American Society of Nephrology, 2009; 20(11):2433-2440 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2009 |
ISSN: | 1046-6673 1533-3450 |
Statement of Responsibility: | Vicki Levidiotis, Sean Chang and Stephen McDonald |
Abstract: | Fertility rates, pregnancy, and maternal outcomes are not well described among women with a functioning kidney transplant. Using data from the Australian and New Zealand Dialysis and Transplant Registry, we analyzed 40 yr of pregnancy-related outcomes for transplant recipients. This analysis included 444 live births reported from 577 pregnancies; the absolute but not relative fertility rate fell during these four decades. Of pregnancies achieved, 97% were beyond the first year after transplantation. The mean age at the time of pregnancy was 29 +/- 5 yr. Compared with previous decades, the mean age during the last decade increased significantly to 32 yr (P < 0.001). The proportion of live births doubled during the last decade, whereas surgical terminations declined (P < 0.001). The fertility rate (or live-birth rate) for this cohort of women was 0.19 (95% confidence interval 0.17 to 0.21) relative to the Australian background population. We also matched 120 parous with 120 nulliparous women by year of transplantation, duration of transplant, age at transplantation +/-5 yr, and predelivery creatinine for parous women or serum creatinine for nulliparous women; a first live birth was not associated with a poorer 20-yr graft or patient survival. Maternal complications included preeclampsia in 27% and gestational diabetes in 1%. Taken together, these data confirm that a live birth in women with a functioning graft does not have an adverse impact on graft and patient survival. |
Keywords: | Humans Pregnancy Outcome Kidney Transplantation Birth Rate Pregnancy Adolescent Adult Middle Aged Female Young Adult |
Description: | © 2009 American Society of Nephrology |
DOI: | 10.1681/ASN.2008121241 |
Published version: | http://dx.doi.org/10.1681/asn.2008121241 |
Appears in Collections: | Aurora harvest Medicine publications |
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