Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/58339
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Type: Journal article
Title: The addition of monosodium glutamate and inosine monophosphate-5 to high-protein meals: effects on satiety, and energy and macronutrient intakes
Author: Luscombe-Marsh, N.
Smeets, A.
Westerterp-Plantagena, M.
Citation: British Journal of Nutrition, 2009; 102(6):929-937
Publisher: C A B I Publishing
Issue Date: 2009
ISSN: 0007-1145
1475-2662
Statement of
Responsibility: 
Natalie D. Luscombe-Marsh, Astrid J. P. G. Smeets and Margriet S. Westerterp-Plantenga
Abstract: In a fed and orally stimulated state, whether the addition of monosodium glutamate (MSG) (alone or in combination with inosine monophosphate-5 (IMP-5)) to a high-protein (HP) meal leads to early satiety and a difference in energy intake at a second course was investigated. Ten men and twelve women consumed, in random order, a first-course meal consisting of: (1) water (control); (2) a HP meal with 0·6 % MSG and 0·25 % IMP-5; (3) a HP meal with no additives; (4) a HP meal with MSG only; (5) a sham-fed meal 2 (oral-stimulation). Appetite perceptions, plasma concentrations of glucagon-like peptide 1 (GLP-1), glucose and insulin, and energy intake at a buffet (i.e. a second course) were measured before and after each condition. Changes in appetite, and in GLP-1, glucose and insulin, were similar for the three fed HP conditions and all were greater (post hoc all P < 0·01) than the control and sham conditions. Energy intake was not different following the HP+MSG+IMP (1·86 (sem 0·3) MJ) as compared with the HP+MSG-only (2·24 (sem 0·28) MJ) condition (P = 0·08), or for the HP+MSG+IMP compared with the HP no-additives condition (1·60 (sem 0·29) MJ) (P = 0·21). Following the HP+MSG-only condition, 0·64 (sem 0·20) MJ more energy was consumed compared with the HP no-additives condition (P = 0·005). We conclude that the addition of MSG to a HP meal does not influence perceptions of satiety and it may increase energy intake at a second course. Cephalic responses after the sham condition were of similar magnitude to the control and therefore just tasting food is not enough to influence appetite and energy intake.
Keywords: Monosodium glutamate; appetite; energy intake; satiety
Rights: Copyright © The Authors 2009
RMID: 0020097038
DOI: 10.1017/S0007114509297212
Appears in Collections:Medicine publications

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