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Type: Journal article
Title: Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release
Author: Osei-Kumah, A.
Wark, P.
Smith, R.
Clifton, V.
Citation: Inflammation Research, 2010; 59(5):349-358
Publisher: Birkhauser Verlag Ag
Issue Date: 2010
ISSN: 1023-3830
Statement of
Annette Osei-Kumah, Peter A. B. Wark, Roger Smith and Vicki L. Clifton
Abstract: <h4>Objective</h4>Pregnancy can influence the course of maternal asthma, but the mechanisms are presently unknown. The aim of the present study was to access maternal immune cell profiles in the presence and absence of asthma and to determine the effect of pregnancy-derived factors on epithelial cell function.<h4>Methods</h4>Cells from the human bronchial epithelial cell line BEAS-2B were treated with plasma from pregnant or nonpregnant asthmatic and nonasthmatic subjects. Cell culture supernatants were collected after 24 h and assayed for IL-6, IL-8, eotaxin, RANTES and sICAM-1 protein using ELISA. Maternal immune cell count and peripheral blood chemotactic response to plasma from pregnant and non-pregnant asthmatic subjects were also assessed.<h4>Results</h4>The presence of maternal asthma during pregnancy was associated with increased monocyte and neutrophil numbers, increased BEAS-2B cell production of IL-8 and sICAM-1 (P < 0.05) and increased chemotactic capacity relative to pregnant women without asthma.<h4>Conclusion</h4>The results of this study suggest that circulating pregnancy-related factors enhance chemotactic mediators in epithelial cells in the presence of asthma. This may be one mechanism that contributes to pregnancy-induced changes in asthma.
Keywords: Chemokine
Immune cells
Bronchial epithelium
Description: The original publication is available at
Rights: © Birkhauser Verlag, Basel/Switzerland 2009
DOI: 10.1007/s00011-009-0102-y
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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