Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/59754
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Type: Journal article
Title: Quantitative description of the regional mechanics of the left atria by electroanatomical mapping
Author: Kuklik, P.
Molaee, P.
Brooks, A.
John, B.
Worthley, S.
Sanders, P.
Citation: Physiological Measurement, 2010; 31(4):555-564
Publisher: IOP Publishing Ltd
Issue Date: 2010
ISSN: 0967-3334
1361-6579
Statement of
Responsibility: 
Pawel Kuklik, Payman Molaee, Anthony G Brooks, Bobby John, Stephen G Worthley and Prashanthan Sanders
Abstract: The left atrium is a complex chamber, which plays an integral role in the maintenance of physiologic hemodynamic and electrical stability of the heart and is involved in many disease states, most commonly atrial fibrillation. Preserving regions of the left atrium that contribute the greatest to atrial mechanical function during curative strategies for atrial fibrillation are important. We present here a new application of the CARTO electroanatomical mapping system in the assessment of the left atria mechanical function. Electroanatomical data were collected in course of the electrophysiological procedure in 11 control patients and 12 patients with paroxysmal atrial fibrillation. The three-dimensional geometry of the left atria was reconstructed in 10 ms intervals and segmented into distinct regions. For each segment, a regional ejection fraction was calculated. We found that anterior, septal and lateral segments have significantly greater regional ejection fraction than atria roof, inferior and posterior segments. Therefore, we hypothesize that in order to minimize the impact on atrial mechanical function, an important determinant of thromboembolic risk, damage should be minimized to these atrial regions.
Keywords: Heart Atria; Heart Conduction System; Humans; Body Surface Potential Mapping; Myocardial Contraction; Algorithms; Models, Cardiovascular; Computer Simulation; Female; Male
Rights: © IOP Publishing 2010
RMID: 0020095799
DOI: 10.1088/0967-3334/31/4/007
Appears in Collections:Medicine publications

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