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https://hdl.handle.net/2440/60369
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Type: | Journal article |
Title: | Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice |
Author: | Yamaza, T. Miura, Y. Akiyama, K. Bi, Y. Sonoyama, W. Gronthos, S. Chen, W. Le, A. Shi, S. |
Citation: | Blood, 2009; 113(11):2595-2604 |
Publisher: | Amer Soc Hematology |
Issue Date: | 2009 |
ISSN: | 0006-4971 1528-0020 |
Statement of Responsibility: | Takayoshi Yamaza, Yasuo Miura, Kentaro Akiyama, Yanming Bi, Wataru Sonoyama, Stan Gronthos, WanJun Chen, Anh Le and Songtao Shi |
Abstract: | Subcutaneous transplants of bone marrow mesenchymal stem cells (BMMSCs) are capable of generating ectopic bone and organizing functional hematopoietic marrow elements in animal models. Here we report that immunocompromised mice received subcutaneous BMMSC transplants using hydroxyapatite tricalcium phosphate as a carrier suppressed age-related degeneration in multiple organs and benefited an increase in life span extension compared with control littermates. The newly organized ectopic bone/marrow system restores active hematopoiesis via the erythropoietin receptor/signal transducer and activator of transcription 5 (Stat5) pathway. Furthermore, the BMMSC recipient mice showed elevated level of Klotho and suppression of insulin-like growth factor I signaling, which may be the mechanism contributing to the alleviation of aging-like phenotypes and prolongation of life in the treated mice. This work reveals that erythropoietin receptor/Stat5 pathway contributes to BMMSC-organized ectopic hematopoiesis, which may offer a treatment paradigm of reversing age-related degeneration of multiple organs in adult immunocompromised mice. |
Keywords: | Cells, Cultured Mesenchymal Stem Cells Animals Mice, Inbred C3H Mice, Transgenic Humans Mice Mice, Nude Green Fluorescent Proteins Mesenchymal Stem Cell Transplantation Life Expectancy Regeneration Hematopoiesis Immunocompromised Host Aging Phenotype Female |
Rights: | Copyright © 2009 by American Society of Hematology |
DOI: | 10.1182/blood-2008-10-182246 |
Published version: | http://dx.doi.org/10.1182/blood-2008-10-182246 |
Appears in Collections: | Aurora harvest Medicine publications |
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