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Type: Journal article
Title: Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled Type 2 diabetes
Author: Ma, J.
Stevens, J.
Maddox, A.
Wishart, J.
Jones, K.
Clifton, P.
Horowitz, M.
Rayner, C.
Citation: Diabetes Care, 2009; 32(9):1600-1602
Publisher: Amer Diabetes Assoc
Issue Date: 2009
ISSN: 0149-5992
Statement of
Jing Ma, Julie E. Stevens, Kimberly Cukier, Anne F. Maddox, Judith M. Wishart, Karen L. Jones, Peter M. Clifton, Michael Horowitz, and Christopher K. Rayner
Abstract: OBJECTIVE: We evaluated whether a whey preload could slow gastric emptying, stimulate incretin hormones, and attenuate postprandial glycemia in type 2 diabetes. RESEARCH DESIGN AND METHODS: Eight type 2 diabetic patients ingested 350 ml beef soup 30 min before a potato meal; 55 g whey was added to either the soup (whey preload) or potato (whey in meal) or no whey was given. RESULTS: Gastric emptying was slowest after the whey preload (P < 0.0005). The incremental area under the blood glucose curve was less after the whey preload and whey in meal than after no whey (P < 0.005). Plasma glucose-dependent insulinotropic polypeptide, insulin, and cholecystokinin concentrations were higher on both whey days than after no whey, whereas glucagon-like peptide 1 was greatest after the whey preload (P < 0.05). CONCLUSIONS: Whey protein consumed before a carbohydrate meal can stimulate insulin and incretin hormone secretion and slow gastric emptying, leading to marked reduction in postprandial glycemia in type 2 diabetes.
Keywords: Humans
Diabetes Mellitus, Type 2
Gastrointestinal Hormones
Blood Glucose
Dietary Proteins
Gastric Emptying
Middle Aged
Glucagon-Like Peptide 1
Rights: © 2009 by the American Diabetes Association.
DOI: 10.2337/dc09-0723
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