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Type: Journal article
Title: microRNAs and EMT in mammary cells and breast cancer
Author: Wright, J.
Richer, J.
Goodall, G.
Citation: Journal of Mammary Gland Biology and Neoplasia, 2010; 15(2):213-223
Publisher: Kluwer Academic/plenum Publ
Issue Date: 2010
ISSN: 1083-3021
Statement of
Josephine A. Wright, Jennifer K. Richer and Gregory J. Goodall
Abstract: MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.
Keywords: microRNA; epithelial to mesenchymal transition; mammary cells; breast cancer
Rights: © Springer. Springer Science+Business Media
RMID: 0020097764
DOI: 10.1007/s10911-010-9183-z
Appears in Collections:Medicine publications

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